How ketamine treatment works
The Ketamine interacts with various receptors and chemicals inside the brain. This interaction results in anti-depressant style effects which can be seen in patients with even Treatment Resistant Depression, which is known for being very difficult to treat with standard mood disorder treatment options.
Ketamine works in this manner because it is a NMDA receptor antagonist and an AMPA receptor stimulator. The stimulation of AMPA increases BDNF, or brain derived neurotrophic factors. When BDNF is increased, this stimulates new receptor and synapses formation, resulting in improved symptoms for people with mood disorders such as major depressive disorder, insomnia, and more. Current research indicate that many of the symptoms associated with these type of mood disorders are associated with weakened receptor and synapses deficiencies, so the stimulation of new receptor and synapsis production can help alleviate or even eliminate certain symptoms.